75 articles - From Friday Sep 09 2022 to Friday Sep 16 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Clin Gastroenterol Hepatol |
AGA Clinical Practice Update on the Evaluation and Management of Acute Kidney Injury in Patients with Cirrhosis: Expert Review. These Best Practice Advice (BPA) statements were drawn from a review of the published literature and from expert opinion. Since systematic reviews were not performed, these BPA statements do not carry formal ratings of the quality of evidence or strength of the presented considerations. |
| Hepatology |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
Systematic review: the role of psychological stress in inflammatory bowel disease. Psychological stress appears to precede IBD exacerbation, although what role it plays in psychosocial outcomes and how it is best managed is unclear. Further research needs to examine the differential effects of stress on disease subtypes and IBD in flare and remission. |
| Gastrointest Endosc |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
Comparison of gastrointestinal landmarks using the gas-sensing capsule and wireless motility capsule. Key anatomical landmarks are accurately identified with the gas-sensing capsule in healthy individuals. Intra-individual differences in transit times between capsules are probably due to physiological factors. Studies in populations with gastrointestinal diseases are now required. |
| Am J Gastroenterol |
Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multi-Center Analysis. CDH1 carriers have colorectal neoplasia identified at similar rates as the general population. Despite potential difficulties after gastrectomy, colorectal cancer screening remains important in this population. |
Correction and prevention of hyponatremia in patients with cirrhosis and ascites - Post hoc analysis of the ANSWER study database. Long-term albumin administration improves hyponatremia and reduces episodes of at least moderate hyponatremia in outpatients with cirrhosis and ascites. |
Isolated Hepatitis B core antibody positivity and long-term liver-related mortality in Korea: A cohort study. In this cohort of Korean adults, isolated anti-HBc positivity was associated with an increased risk of liver-related and liver cancer mortality, especially when accompanied by a high fibrosis score. Isolated anti-HBc positivity may be an independent risk factor for liver-related outcomes, especially in high-endemic areas. |
Modest conformity between self-reporting of Bristol stool form and fecal consistency measured by stool water content in irritable bowel syndrome, a FODMAP and gluten trial. Subjective reporting of BSFS conforms only modestly with stool water content in IBS, warranting caution when subtyping IBS according to BSFS. High intake of FODMAP and gluten does not affect stool water content. |
The assessment of driving fitness using an on-road driving evaluation in patients with cirrhosis. Worse performance on in-office testing was associated with worse scores on a computerized driving assessment battery and more on-road driving errors, but in-office tools were insufficient to predict on-road driving failures. A diagnosis of MHE should not be used alone to restrict driving in patients with cirrhosis. At-risk patients require on-road driving tests under the supervision of driving regulatory agencies. Future studies should continue to refine and evaluate in-office or at-home testing to predict driving performance. |
| Clin Gastroenterol Hepatol |
A Prospective Cohort Study Evaluating PAN-PROMISE, a Patient-Reported Outcome Measure To Detect Post-ERCP Morbidity. A substantial number of patients experience significant morbidity after ERCP despite not developing PEP or other adverse events. Future studies are needed to characterize better the reasons behind this increase in symptoms and potential interventions to reduce the symptom burden post-ERCP. number, NCT05310409. |
ATP7B genotype and chronic liver disease treatment outcomes in Wilson disease: worse survival with loss of function variants. Patients with WD and CLD phenotype on chelators, who have at least one LOF variant in ATP7B, have a worse prognosis during long-term follow up. This subgroup of patients requires close monitoring for signs of progressive liver disease. Sequencing of ATP7B may be used in the diagnosis of WD, in addition it may provide useful prognostic information for patients with hepatic WD. |
DEVELOPMENT AND VALIDATION OF A NATIONAL US ACHALASIA COHORT: THE VETERANS AFFAIRS ACHALASIA COHORT (VA-AC). Using a rigorous validation approach, we established a national cohort of 2,100 individuals with achalasia within the VHA, one of the largest established to date. This cohort can be utilized to study risk factors for achalasia and outcomes over time. |
Inflammatory Bowel Disease is associated with an Increased Risk of Incident Acute Arterial Events: Analysis of the United Kingdom Biobank. In a prospective cohort, there was an increased risk of incident AAEs and premature AAEs in IBD participants. Beyond traditional AAE risk factors, quantifiable indices of IBD disease activity and severity were independent predictors of AAEs. |
| Endoscopy |
The course of pain and dysphagia after radiofrequency ablation for Barrett's esophagus-related neoplasia. RFA treatment for BE-related neoplasia seems a significant burden for patients, and post-procedural symptoms should be taken into account when counseling patients before starting endoscopic eradication therapy. |
| Gastroenterology |
Molecular markers of response to anti-PD1 therapy in advanced hepatocellular carcinoma. IFN-signaling and MHCII-related genes are key molecular features of HCCs responding to anti-PD1. A novel 11-gene signature predicts response in frontline aHCC - but not in patients pre-treated with TKIs. These results have to be confirmed in prospective studies and highlight the need for biopsies prior immunotherapy to identify biomarkers of response. |
| Gastrointest Endosc |
Covered versus uncovered double bare self-expandable metal stent for palliation of unresectable extrahepatic malignant biliary obstruction: A randomized controlled multicenter trial. The use of PCDBS, compared with UCDBS, in patients with distal MBO has unclear bene |
Genotype-phenotype correlation of small intestinal polyps on small-bowel capsule endoscopy in familial adenomatous polyposis. In familial adenomatous polyposis patients, Small-bowel capsule endoscopy surveillance is potentially recommended for patients with pathogenic variants in the APC gene at codons 278 and 1062-1504 or with Spigelman stage III or higher. |
| Hepatology |
c-Rel dependant Chk2 signalling regulates the DNA damage response limiting hepatocarcinogenesis. Hepatocyte c-Rel signalling limits genotoxic injury, and subsequent HCC burden. Inhibiting c-Rel as an adjuvant therapy increased the effectiveness of DNA damaging agents and reduced HCC growth. |
CD11b+ CD43hi Ly6Clo splenocyte-derived macrophages exacerbate liver fibrosis via spleen-liver axis. CD11b + CD43 hi Ly6C lo splenic monocytes migrate into liver and shift to macrophages, which account for the exacerbation of liver fibrosis. These findings reveal precise mechanisms of spleen-liver axis in hepatic pathogeneisis, and shed light on the potential of sM-1 as candidate target for controlling liver diseases. |
Combinatorial targeting of GPBAR1 and CYSLTR1 reveals a mechanistic role for bile acids and leukotrienes in drug induced liver injury. By genetic and pharmacological approaches, we demonstrated that GPBAR1 and CYSLTR1 mutually interact in development of DILI. A combinatorial approach designed to activate GPBAR1 while inhibiting CYSLTR1, reverses liver injury in models of DILI. |
NRPT reduces markers of hepatic inflammation in non-alcoholic fatty liver disease: a double-blind, placebo-controlled clinical trial. This study demonstrates that NRPT at the recommended dose is safe and may hold promise in lowering markers of hepatic inflammation in patients with NAFLD. |
| J Hepatol |
Evaluation of CirrhoCare® - A digital-health solution for home management of patients with cirrhosis. CirrhoCare® managed patients had fewer and shorter hospital readmissions, as well as less unplanned abdominal fluid drains than in a control group. CirrhoCare® is a promising tool for specialist, community management of cirrhosis patients, at-risk of new cirrhosis complications. |
Human duodenal submucosal glands contain a defined stem/progenitor subpopulation with liver-specific regenerative potential. A cell population with clonal growth and organoid formation capability, and which has liver differentiation potency in vitro and in vivo in murine experimental models, is present within adult duodenal submucosal glands. These cells can be isolated, do not require reprogramming, and thus could potentially represent a novel cell source for regenerative medicine of the liver. |
Low dose interleukin-2 selectively expands circulating regulatory T cells but fails to promote liver allograft tolerance in humans. The expansion of circulating Tregs in response to LDIL-2 is not sufficient to control alloimmunity and to promote liver allograft tolerance, due, at least in part, to off-target effects that increase the liver immunogenicity. Our trial provides unique insight into the mechanisms of action of immunomodulatory therapies such as LDIL-2 and their limitations in promoting alloantigen-specific effects and immunological tolerance. |
Viral clade is associated with severity of symptomatic genotype 3 Hepatitis E virus infections in Belgium, 2010-2018. In symptomatic HEV gt3 infections, clade efg is associated with a more severe disease presentation, higher serum CXCL10 levels and liver necro-inflammatory activity, irrespective of known host risk factors. |
| Neurogastroenterol Motil |
Clinical significance of small bowel manometry patterns suggestive of intestinal obstruction. and inference Currently, the most frequent origin of MRP and PSC encountered on small bowel manometry is intestinal neuropathy, while a previously undetected mechanical obstruction is rare. Still, in a substantial proportion of patients, no underlying disease can be identified, and in them, colonic fecal retention might play a role, because in a subgroup of these patients, manometry normalized after colonic cleansing. Hence, colonic preparation may be considered prior to intestinal manometry. |
Tolerability, gastric emptying patterns, and symptoms during the Nottingham Test Meal in 330 secondary care non-diabetic dyspeptic patients. Gastric scintigraphy with the NTM is simple to perform and well tolerated. Whether the identified abnormal gastric emptying patterns could predict different treatment outcome in patients with functional dyspepsia is the subject of ongoing prospective studies. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
| Gastrointest Endosc |
Comprehensive review of publicly available colonoscopic imaging databases for artificial intelligence research: availability, accessibility and usability. This review provides greater insight on public availability of colonoscopic imaging databases for AI-research. Incomplete reporting of important details limits the ability of researchers to assess the usability of the current databases. |
| Hepatology |
Risk stratification and early detection biomarkers for precision hepatocellular carcinoma screening. In this review, we overview recent developments of clinical, molecular, and imaging-based tools to address the current challenge, and discuss conceptual framework and approaches of their clinical translation and implementation. These encouraging progresses are expected to transform the current "one-size-fits-all" HCC screening into individualized precision approaches to early HCC detection and ultimately improve the poor HCC prognosis in the foreseeable future. |
| J Hepatol |
Blood-based biomarkers for hepatocellular carcinoma screening: Approaching the end of the ultrasound era? While there are several promising biomarkers awaiting validation, in order to supplant abdominal ultrasound, a candidate biomarker must show adequate test performance as well as overcome practical hurdles to ensure adoption in clinical practice. The promise of blood-based biomarker is significant, especially given the limitations of ultrasound-based screening; however, adequate validation and several logistical considerations are required prior to clinical implementation. |
| Neurogastroenterol Motil |
Anti-inflammatory effects of vagal nerve stimulation with a special attention to intestinal barrier dysfunction. In particular, the VN can act on intestinal permeability through enteric nerves, and/or cells such as enteric glial cells. We also review the existing evidence of the effects VNS on intestinal permeability in models such as burn intestinal injury and traumatic brain injury, which pave the way for future clinical trials in IBD, IBS, and celiac disease. |
Rectocele: Incidental or important? Observe or operate? Contemporary diagnosis and management in the multidisciplinary era. In this cohort, the perioperative data, efficacy, and harms outcomes are comparable with historical data predominantly derived from retrospective series in which patients had a good outcome (67%-78%), symptoms of difficult defecation improved (30%-50%), and patients had a recurrent rectocele 2 |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
| Clin Gastroenterol Hepatol |
| Hepatology |
| J Hepatol |
| Neurogastroenterol Motil |